Pododermatitis is defined as inflammation of the skin of the paw, It is often the cause of swollen, red and itchy feet, which can progress to painful sores if left untreated.
Pododermatitis can be caused by many disorders including infections, allergies, hormonal disorders, immune-mediated diseases, tumors or cancers, environmental contaminants, Parasites and foreign bodies.
It is a transverse condition, affecting several species of animals, especially rabbits and guinea pigs, primarily for anatomical reasons . Unlike dogs and cats, whose legs are protected by bearings, in the Rabbit only the fur covers the skin, even in the lower part, and under the skin, there is not enough soft tissue to cushion the friction between bone and skin. This condition is aggravated when the legs contact hard surfaces. 
For a correct diagnosis can be necessary evaluating medical history of the patient and clinical signs as well as skin cytology and skin scrapings. Hair plucks are performed to diagnose Demodex mite infestation.
The parasitic mite Demodex can infect the haired skin, Pododermatitis is usually linked to hair loss, swelling and bleeding sores due to the mites.
Foreign bodies like grass seeds tend to penetrate the skin of the feet. Foreign bodies are particularly likely when a lesion is present on one foot and it is easy to note this because the patients often lick the affected sites.
The most common triggers for allergic pododermatitis are food items and environmental substances such as dust mites and pollens
This usually occurs in heavy set dogs with very large paws and consists in inflammation of the hair follicles. If this inflammation becomes chronical, it can cause pain with swollen lumps around the toes.
Certain hormonal diseases like thyroid gland (hypothyroidism) or overactive adrenal glands (Cushing’s disease) can also be involved in the development of pododermatitis, even if it is a relatively rare symptom
Once the underlying cause is determined, treatment will be directed toward that cause. If the pododermatitis has an allergic or immune-mediated cause, it is important to note that the condition cannot be cured. In these cases, the therapeutic goal is to minimize clinical signs and recurrences.2]
Among useful treatments we need to consider a lifestyle change, with proper nutrition and right movement, in particular in presence of conformation or connected-food causes. Topical therapy such as shampoo washes, foot soaks, or wipes for secondary bacterial and yeast infections is required. 
Oral antibiotics and anti-fungals may be required for more severe cases. In addition, corticosteroids and immune modulating drugs can be used. Local therapy, with bandages, creams and ointments, scarring products for decubitus ulcers, laser therapy or PRP can be very useful in the approach and treatment for this disease.
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